A wide range of use of painkillers and antipyretics is part of our everyday life. Among the medications, calmopyrine and aspirin often arise as alternatives that serve to alleviate various symptoms. The mechanisms of action, side effects, and areas of application of these medications differ; however, both are popular choices among patients. The selection of the appropriate medication often depends on the nature of the symptoms and the individual health condition of the patient. When using calmopyrine and aspirin, it is important to consider that these agents not only have pain-relieving properties but also possess anti-inflammatory and antipyretic effects. Both medications belong to the group of non-steroidal anti-inflammatory drugs (NSAIDs),…